TPI1 promotes malignant progression and ferroptosis resistance in head and neck squamous cell carcinoma.
- Open access
TPI1 is overexpressed in head and neck squamous cell carcinoma and promotes tumor progression by conferring ferroptosis resistance, with high expression predicting poor survival.
- Why it matters: Understanding the molecular mechanisms behind ferroptosis resistance in HNSCC is crucial for developing effective therapies, as resistance enables tumor survival and progression.
- What they did: The study analyzed TPI1 expression across 33 cancers, validated its upregulation in HNSCC tissues, and used cell-based assays, single-cell sequencing, and spatial transcriptomics to explore its role and mechanisms.
- The result: TPI1 enhances malignant behaviors and ferroptosis resistance in HNSCC cells, serving as an independent prognostic biomarker and a potential therapeutic target to overcome ferroptosis evasion.