Emergent 3D genome reorganization and graded gene control from the stepwise assembly of transcriptional condensates.
- Open access
Stepwise assembly of transcriptional condensates enables graded 3D genome reorganization during yeast heat shock response.
- Why it matters: Understanding how transcriptional condensates form and function is crucial for revealing mechanisms of gene regulation and cellular adaptation, yet these processes are not fully understood.
- What they did: The study used mutants and molecular analysis to track the sequential formation of condensates involving Hsf1, Mediator, and Pol II during the heat shock response in yeast, revealing a graded control mechanism.
- The result: Fully assembled condensates allow both fine-tuned gene expression and 3D genome restructuring, indicating condensates have roles beyond transcription regulation and enabling adaptive cellular responses.