Cellular & molecular immunology · 1 Sept 2026 · Letter

The FAM234A-USP4 axis governs T-cell fate through the dual regulation of mTOR and RORγt.

Wang, Fang

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p97-mediated proteostasis is a checkpoint for late-stage thymocyte positive selection.
Cellular & molecular immunology · 1 Oct 2026 · Journal Article
p97 is essential for late-stage thymocyte positive selection, with its loss causing a severe blockade in CD8+ lineage commitment and thymocyte development.
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The molecular glue CLEO4-88 inhibits the ACAA1 thiolase by induced binding to GID4.
Nature Chemical Biology · 1 Oct 2026 · Journal Article
CLEO4-88 acts as a molecular glue with an EC50 of 12.5 nM to inhibit ACAA1 thiolase by inducing binding to GID4 in vitro and in cells.
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Recruiting without destroying.
Nature Chemical Biology · 1 Oct 2026 · Journal Article
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