Mechanisms of key gut microbial metabolites: SCFAs, BAs, and TDMs.

Gut microbial metabolites like SCFAs, BAs, and TDMs regulate host immunity, metabolism, and neural functions through diverse signaling pathways, impacting health and disease.

• Why it matters: Understanding these metabolites is crucial because disruptions in their pathways are linked to inflammatory diseases, neurodegeneration, and cancer, highlighting a significant health challenge.
• What they did: The review analyzes how SCFAs, BAs, and TDMs act as signaling molecules, receptor ligands, and epigenetic modulators, exploring their molecular mechanisms and therapeutic potential across various host systems.
• The result: Insights from this work pave the way for targeted therapies that modulate microbial metabolites, offering promising strategies for treating complex diseases and advancing clinical applications.