Amygdala astrocyte primary cilium mechanisms contribute to stress behaviours.

Amygdala astrocyte primary cilia disruption during stress impairs behavior, but restoring cilia improves stress responses and molecular markers.

• Why it matters: Understanding how stress alters brain cell functions is crucial for developing targeted treatments for stress-related disorders, which remain poorly managed.
• What they did: The study used chemogenetics and genetic targeting of S1PR1 GPCRs in amygdala astrocytes, analyzing protein, gene expression, and behavior in mice and human tissue, focusing on primary cilia.
• The result: Restoring astrocyte primary cilia length corrected molecular changes and improved stress behaviors, suggesting cilia-related mechanisms as potential therapeutic targets for brain disorders.