Systemic health impact of cancer-associated extracellular vesicles and particles.

Cancer-associated extracellular vesicles and particles cause widespread systemic dysfunction, affecting multiple organs and contributing to disease progression and host mortality.

• Why it matters: Understanding how cancer influences distant tissues is crucial for developing comprehensive treatments that address not only tumor growth but also systemic health impacts and comorbidities.
• What they did: The review examines the roles of tumor-derived EVPs in preparing pre-metastatic niches, immune evasion, and organ system manipulation, involving over 100 studies on their systemic effects and interactions with host, diet, and microbiota EVPs.
• The result: Targeting EVPs offers promising systemic therapeutic strategies to mitigate cancer’s broad effects, improve patient quality of life, and enhance survival by addressing both tumor and paraneoplastic organ dysfunctions.