Multiscale evolution of the 3D genome.

Multiscale analysis reveals rapid evolution of genome architecture in cancer and diverse divergence across species, with recurrent features indicating functional convergence.

• Why it matters: Understanding how genome structure evolves across different biological scales is crucial for insights into development, disease, and evolutionary processes, yet remains incomplete.
• What they did: The review synthesizes research on 3D genome evolution at cellular, species, and phylogenetic levels, highlighting rapid changes in cancer and divergence driven by local genomic alterations.
• The result: This framework clarifies how genome architecture diversity relates to evolution of form and function, enabling better comprehension of genome dynamics and their biological implications.