bioRxiv · 11 Sept 2026 · Preprint · Open access

Collaborative binding by diverse pioneer transcription factors amplifies Polycomb repression to preserve lineage fidelity

Mirizio, Buckley + 5 more

Open access

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The transcription factor BACH1 couples chromatin priming and repression to enable macrophage plasticity and adaptation.
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BACH1 acts as a pioneer repressor, priming chromatin and regulating macrophage plasticity with 3D architecture constraints, crucial for tissue adaptation and inflammation responses.
- Open access
- 3 cites
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An encyclopedia of human enhancer-gene regulatory interactions.
Nature · 1 Sept 2026 · Journal Article
A comprehensive resource of over 92 million human enhancer-gene interactions across 369 tissues advances understanding of gene regulation and disease genetics.
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Cumulative transcription factor binding and p300-mediated histone acetylation drive enhancer activation frequency.
Nature Genetics · 1 Aug 2026 · Journal Article
Cumulative transcription factor binding and p300 activity determine enhancer activation frequency in eukaryotic cells.
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