Reelin Deficiency Alters the Directional Orientation, Apical Localization and Length of Primary Cilia in Principal Neurons in the Cerebral Cortex

Reelin deficiency causes persistent disruptions in primary cilia orientation, localization, and length in principal neurons of the cerebral cortex, especially in laminated regions.

• Why it matters: Understanding how primary cilia are regulated is crucial because they influence neuronal development and function, yet the mechanisms controlling their orientation and length remain unclear, impacting neurodevelopmental research.
• What they did: The study examined primary cilia in various neuron types using Reelin-deficient mice, analyzing their orientation, localization, and length across developmental stages and brain regions, focusing on principal neurons.
• The result: Reelin deficiency alters cilia orientation, apical localization, and increases cilia length in principal neurons, impairing their development and suggesting Reelin's vital role in ciliogenesis and neuronal polarity.