bioRxiv · 3 Sept 2026 · Preprint · Open access

The myocyte Nfe2l1-ubiquitin-proteasome system controls muscle fiber type and obesity-induced insulin resistance

Lemmer, Haas + 22 more

Open access
3 cites

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ABTB1, as an E3 ubiquitin ligase, suppresses Th17 cell differentiation and mitigates autoimmune inflammation by promoting STAT3 ubiquitination and degradation.
Cellular & molecular immunology · 1 Oct 2026 · Journal Article
ABTB1 functions as an E3 ubiquitin ligase that suppresses Th17 cell differentiation by promoting STAT3 degradation, reducing autoimmune inflammation.
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Recruiting without destroying.
Nature Chemical Biology · 1 Oct 2026 · Journal Article
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p97-mediated proteostasis is a checkpoint for late-stage thymocyte positive selection.
Cellular & molecular immunology · 1 Oct 2026 · Journal Article
p97 is essential for late-stage thymocyte positive selection, with its loss causing a severe blockade in CD8+ lineage commitment and thymocyte development.
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