Wdr82-COMPASS coordinates Foxp3 and TCR signaling to sustain T(reg) cell control of microbiota-driven intestinal inflammation.

Wdr82/COMPASS-mediated H3K4me3 epigenetic regulation is linked to Foxp3 induction and sustains T reg cell control of microbiota-driven intestinal inflammation.

• Why it matters: It remains unclear how broadly acting epigenetic pathways are selectively used by T reg versus T conv cells to maintain tolerance in the gut.
• What they did: The study identified Wdr82 as a COMPASS component and used T cell-specific deletion to test effects on T reg development/function, microbiota dependence, and chromatin at T reg genes.
• The result: Wdr82 deficiency causes progressive, microbiota-dependent intestinal inflammation and inflammatory T conv expansion, which is prevented by microbiome depletion or wild-type T reg transfer, implying a primary T reg tolerance defect.