StSIRT1 regulates potato dormancy through deacetylation of peroxidase-like 3 at K37.

StSIRT1-mediated deacetylation of StPRX3 at lysine-37 (K37) suppresses peroxidase activity and is linked to potato dormancy release.

• Why it matters: Dormancy is crucial for plant survival and agronomic performance, yet how posttranslational modification of nonhistone proteins regulates dormancy remains unclear.
• What they did: In potato (Solanum tuberosum L.), StSIRT1 deacetylates StPRX3, lowering K37 acetylation and reducing StPRX3-driven H2O2 scavenging capacity during dormancy release.
• The result: The StPRX3 K37R mutant suppresses peroxidase activity and accelerates dormancy release, revealing an StSIRT1–StPRX3 cascade that reduces H2O2 levels.