Double-base deletions and signatures associated with platinum adducts in metastatic cancer.

A platinum-associated double-base substitution signature with GG deletion as the dominant feature was identified in a large pan-cancer metastatic cohort.

• Why it matters: Understanding the mutational signatures linked to platinum compounds is crucial for insights into their genomic effects and potential resistance mechanisms in cancer therapy.
• What they did: The study generated platinum-specific de novo double-base substitution and deletion signatures, revealing a signature with GG deletion and other platinum-related substitutions, and found TT deletions associated with microsatellite instability.
• The result: These signatures enhance the catalog of platinum-induced mutations and may facilitate the discovery of new biological insights, including links to microsatellite instability in multiple cohorts.