Orbitofrontal value dynamics and striatal population geometry during interruption of automatic behavior.

OFC population dynamics vacillate between competing value states and disrupt striatal population geometry during automatic behavior interruption in monkeys.

• Why it matters: Understanding how the brain interrupts automatic responses is crucial for insights into cognitive control and related disorders involving OFC and caudate nucleus interactions.
• What they did: Researchers recorded simultaneous Neuropixels data from OFC and caudate nucleus in monkeys performing a decision task with conflicting value representations, focusing on neural dynamics during response correction.
• The result: Findings show that top-down OFC signals disrupt striatal population geometry via synchronization, without altering firing rates, suggesting a mechanism for interrupting automatic responses.