Shared molecular mechanisms between colorectal cancer and cardiovascular disease drive perioperative neurological vulnerability.

A nomogram integrating seven clinical predictors achieves an 83.5% C-index for perioperative delirium prediction in elderly colorectal cancer patients.

• Why it matters: Perioperative delirium is a common complication linked to shared molecular pathways between colorectal cancer and cardiovascular disease, but effective risk stratification tools are lacking.
• What they did: Researchers analyzed data from 283 elderly CRC patients, assessing frailty, biomarkers, and intraoperative factors, then developed and validated a predictive nomogram using multivariate logistic regression and internal validation methods.
• The result: The nomogram demonstrated high predictive accuracy and clinical utility, supporting its use in personalized perioperative management and highlighting the molecular convergence underlying neurovascular vulnerability.