Gut microbiota and metabolic characteristics in PWHIV with metabolic dysfunction-associated steatotic liver disease (MASLD).

Gut microbiota and metabolite alterations in PWHIV with MASLD are linked to inflammation and oxidative stress, with Faecalibacterium and Anaerobutyricum notably decreased.

• Why it matters: Understanding these microbial and metabolic changes is crucial because they may drive MASLD progression in PWHIV, a group with a high prevalence of the disease.
• What they did: The study analyzed 60 fecal and plasma samples using 16S rRNA sequencing and LC/MS-based metabolomics, identifying specific microbial shifts and metabolite variations associated with MASLD.
• The result: Findings suggest that modulating gut microbiota could be a therapeutic approach, and plasma metabolites may serve as noninvasive markers for MASLD diagnosis and monitoring.