Enriched Adaptive Immunity and Reduced Inflammatory Response in Plasma Cell Disorders of Self-Identified Black Patients.

Self-identified Black patients with plasma cell disorders exhibit enriched adaptive immunity and reduced inflammatory responses, with notable immune cell composition differences.

• Why it matters: Understanding immune microenvironment variations in Black patients is critical, as they face higher risks and may respond differently to treatments, yet this remains poorly characterized.
• What they did: Mass cytometry and scRNA-seq analyzed 128 bone marrow samples, revealing immune cell shifts and gene expression patterns associated with race and disease progression, validated in an independent cohort of 286 MM patients.
• The result: Findings show race-related immune remodeling, including higher terminal T cells and lower monocytes, which could influence disease biology and inform personalized treatment strategies.