Longitudinal Surgical Modeling of Early Glioblastoma Recurrence Reveals Emergence of Margin-Associated Neural Programs.

Maximal Safe Intracranial Surgery (MSIS) enables reproducible modeling of post-surgical glioblastoma recurrence, revealing margin-associated neural programs in five mouse models.

• Why it matters: Understanding tumor recurrence after surgery is crucial for improving glioblastoma treatment, yet current models lack precise replication of surgical procedures and tissue sampling.
• What they did: The team developed MSIS, a neurosurgical system combining a miniaturized resection device with multi-regional biopsy, applied across five orthotopic brain tumor models to study post-surgical tumor dynamics.
• The result: Recurrent tumors showed enrichment of neural transcriptional states linked to neuron-glioma signaling at tumor margins, providing insights into recurrence mechanisms and potential therapeutic targets.