Myogenic differentiation-derived small extracellular vesicles as a therapeutic strategy for miR-193b-3p-mediated muscle regeneration.
- Open access
Small extracellular vesicles carrying miR-193b-3p promote muscle regeneration by targeting AP2M1, with a significant impact observed in vitro and in vivo.
- Why it matters: Effective muscle repair requires precise intercellular communication, yet the molecular mechanisms governing this process remain incompletely understood, limiting therapeutic options for muscle-wasting conditions.
- What they did: The study analyzed miR-193b-3p levels in EVs during human myogenic differentiation and tested its effects through EV and synthetic delivery in cell cultures and a mouse muscle injury model, identifying its target AP2M1.
- The result: Findings demonstrate that miR-193b-3p enhances muscle regeneration by suppressing AP2M1, a negative regulator, highlighting the miR-193b-3p-AP2M1 axis as a promising therapeutic target for muscle-wasting diseases.