Sex-biased expression of enteroendocrine cell-derived hormones contributes to higher fat storage in Drosophila females.

Gut-specific knock-down of enteroendocrine hormones AstC and Tk reduces fat storage exclusively in female Drosophila, highlighting sex-biased hormonal regulation.

• Why it matters: Understanding sex differences in hormonal regulation is crucial for revealing mechanisms underlying physiological and behavioral disparities between males and females, which can inform targeted interventions for metabolic health.
• What they did: The study characterized sex-biased expression of EE cell-derived hormones in Drosophila and used RNA interference to knock down these hormones specifically in the gut, measuring resulting triglyceride levels in both sexes.
• The result: Findings demonstrate that reducing AstC and Tk hormones in the gut decreases fat storage in females but not males, indicating sex-specific hormonal control of fat metabolism and potential pathways for sex-tailored metabolic regulation.