Tumor-immune microenvironment and nutritional status biomarkers predict recurrence after total colectomy for locally advanced colon cancer: development and internal validation of a nomogram.
- Open access
A nomogram combining tumor-immune and nutritional biomarkers predicts 3-year recurrence with 84.1% accuracy after total colectomy for advanced colon cancer.
- Why it matters: Accurate risk stratification is essential to improve post-surgical management and tailor therapies, yet no validated tool integrates immune and nutritional factors for this purpose.
- What they did: Researchers analyzed 341 patients with stage II-III colon cancer, assessing immune markers (MMR, TIL, PD-L1, NLR) and nutritional indicators (albumin, NRS 2002), then developed and validated a predictive nomogram.
- The result: The model demonstrated high predictive performance, outperforming clinical-only models, and offers a promising tool for guiding postoperative treatment decisions, pending further validation.