Integrating single-cell multi-omics for precision radiotherapy stratification in hypopharyngeal squamous cell carcinoma.
- Open access
A 9-gene signature predicts radiotherapy outcomes in hypopharyngeal squamous cell carcinoma with over 82% accuracy at 1 year.
- Why it matters: HPSCC has a poor prognosis and high recurrence rate despite radiotherapy, highlighting the need for precise prognostic tools to improve treatment strategies.
- What they did: Researchers integrated single-cell multi-omics data, analyzed gene modules related to radiation response, and developed a 9-gene prognostic signature validated across multiple datasets.
- The result: The signature enables stratification of patients into risk groups, revealing immune microenvironment differences and potential targets for personalized therapy, pending further clinical validation.