Perceptions of and willingness to participate in genomics research among a U.S. sample.

Sixty-two percent of transgender adults are willing to participate in genomics research, but concerns about harm and mistrust remain significant barriers.

• Why it matters: Understanding transgender individuals' perspectives on genomics research is crucial to prevent harm and ensure ethical engagement, especially as biobanks increasingly collect gender identity data.
• What they did: A nationwide survey of 495 transgender adults assessed sociodemographics, policy, health, and attitudes toward genomics research, with regression models identifying factors influencing perspectives and willingness.
• The result: Positive perceptions strongly predicted willingness to participate (OR=14.48), highlighting the need for trust-building and safety measures to foster inclusive and ethical transgender genomics research.