A splicing checkpoint licenses resistosome assembly.
PTI activates alternative splicing of potato NLR Rpi-vnt1.1 mRNA, removing a repressive prodomain and enabling immune response, revealing a new immune regulation layer.
- Why it matters: Understanding how plants coordinate different immune pathways is crucial for improving disease resistance, as current knowledge of the molecular links remains limited.
- What they did: Gao et al. analyzed the splicing patterns of Rpi-vnt1.1 mRNA following PTI activation, demonstrating that PTI induces specific splicing changes that promote immune readiness.
- The result: This finding uncovers a splicing-based checkpoint that licenses resistosome assembly, offering potential targets for enhancing plant immunity and disease resistance strategies.