Targeting liver angiotensinogen with siRNA enhances podocyte regeneration through renin lineage cells in experimental kidney disease.
- Open access
Liver-targeted AGT siRNA increases CoRL-derived podocytes by 85% in kidney disease, promoting regeneration without immediate functional improvements.
- Why it matters: Chronic kidney disease progression involves complex mechanisms, and targeting the renin-angiotensin system (RAS) with siRNA could offer new therapeutic avenues, but how this affects kidney cell regeneration is unclear.
- What they did: Using renin lineage-tracing mice, researchers administered AGT siRNA to reduce plasma AGT by approximately 85%, observing effects on CoRL-driven glomerular cell repopulation in a 5/6 nephrectomy model.
- The result: While kidney function remained unchanged, AGT silencing significantly increased CoRL-derived parietal epithelial cells and podocytes, suggesting enhanced regenerative potential that may support delayed renal repair.