OsPHO2 promotes the ubiquitin-dependent degradation of OsHMGB1 to fine-tune phosphate homeostasis in rice.
- Open access
OsPHO2 promotes ubiquitin-dependent degradation of OsHMGB1, regulating phosphate homeostasis in rice by controlling PSR gene expression.
- Why it matters: Maintaining phosphate balance is vital for rice growth, but the post-translational mechanisms controlling key regulators like OsHMGB1 were unclear, limiting understanding of Pi regulation.
- What they did: The study used protein interaction assays, ubiquitination tests, and genetic analysis involving mutants and transcriptome profiling to investigate OsHMGB1 degradation and its regulation by OsPHO2.
- The result: Findings show OsPHO2 facilitates OsHMGB1 ubiquitination and degradation, influencing Pi accumulation and PSR gene expression, thus enabling rice to fine-tune phosphate homeostasis.