Building and regenerating intestines by manipulating intestinal stem cells.
Manipulating intestinal stem cells enables the regeneration and repair of human intestines, advancing potential treatments for a wide range of intestinal diseases.
- Why it matters: Intestinal disorders cause diverse pathologies, and harnessing stem cells offers a promising avenue for effective therapies, yet translating this knowledge into clinical applications remains challenging.
- What they did: The ISCC, supported by the National Institute of Diabetes and Digestive and Kidney Diseases from 2009 to 2024, reviewed recent advances in ISC biology, focusing on the human ISC niche, pathogen interactions, and regenerative strategies.
- The result: This work consolidates current knowledge and identifies gaps, paving the way for stem cell-based therapies that could improve mucosal repair and generate functional intestinal tissue ex vivo.