BMJ · 27 Aug 2026 · Journal Article

Pancreatic cancer: US approves "breakthrough" drug that may double survival time.

Iacobucci

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RevMed's RAS inhibitor gains landmark FDA approval for pancreatic cancer.
Nature Reviews Drug Discovery · 27 Aug 2026 · News
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Acquired resistance to the RAS(ON) multi-selective inhibitor daraxonrasib guides rational combination therapy strategies in pancreatic cancer.
Nature Medicine · 1 Aug 2026 · Clinical Trial, Phase II
Over 59% of pancreatic cancer patients treated with daraxonrasib develop resistance through RAS pathway alterations, including KRAS amplification and RTK upregulation.
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- 5 cites
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CDK8 remodels the tumor microenvironment and promotes resistance to KRAS(G12D) inhibitors and daraxonrasib in PDAC.
EMBO Journal · 1 Aug 2026 · Journal Article
CDK8 drives immune evasion and resistance in PDAC by remodeling the tumor microenvironment during KRAS G12D inhibition, with 50% of cases showing resistance.
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- 3 cites
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