Determinants of mutation susceptibility along the genome are largely invariant across human tissues.
- Open access
Genomic factors influencing mutation susceptibility are largely consistent across 25 human tissues, with chromatin structure and sequence context playing key roles.
- Why it matters: Understanding the determinants of mutation rates across tissues is crucial for insights into tumor evolution, somatic mosaicism, and age-related diseases, yet their relative importance remains unclear.
- What they did: A modeling approach integrating 146 genomic features was used to predict mutation susceptibilities in coding and non-coding regions across diverse tissues, including unseen types.
- The result: The findings show that mutation rate dependencies on chromatin and genomic features are conserved across tissues, enabling accurate predictions and advancing knowledge of mutagenic processes.