Gut · 19 Aug 2026 · Journal Article · Open access

Intestinal flagellin drives multisystem inflammation through TLR5-IL-15-ARA axis.

Geng, Zhu + more

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Macrophage-Induced Senescent Cancer-Associated Fibroblasts Promote SASP-Mediated Chemoresistance in Colorectal Cancer.
Cancer Research · 2 Oct 2026 · Journal Article
Macrophage-induced senescent cancer-associated fibroblasts drive 78% chemoresistance in colorectal cancer via SASP factors IL6 and CXCL12.
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IL-1α Expands SLC2A1highSPP1highIFNlow Myeloid Cells to Drive Immune Escape and Malignant Transformation of Precancers.
Cancer Research · 2 Oct 2026 · Journal Article
IL-1α drives expansion of SLC2A1highSPP1highIFNlow myeloid cells, promoting immune escape and malignant transformation in pre-cancerous head and neck lesions.
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Neutrophil-Driven Trogocytosis in Pancreatic Ductal Adenocarcinoma Liver Metastases Restrains Immunosuppressive Macrophage Polarization and Limits Metastatic Progression.
Gastroenterology · 1 Oct 2026 · Journal Article
Neutrophils limit immunosuppressive macrophage polarization in PDAC liver metastases through trogocytosis, reducing metastatic progression by 50%.
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