PKA-dependent phosphorylation drives stress granule maturation and controls recovery from prolonged starvation.

PKA-dependent phosphorylation induces stress granule maturation into solid-like states during prolonged starvation in yeast.

• Why it matters: Understanding how stress granules mature is crucial because their insoluble aggregates are linked to neurodegenerative diseases, and controlling this process could improve cell survival under chronic stress.
• What they did: The study used yeast cells to investigate stress granule dynamics, revealing that PKA activity within granules phosphorylates key proteins like Cdc19, leading to amyloid-like maturation during long-term stationary phase.
• The result: Inhibiting PKA prevents stress granule maturation, alters metabolism, and delays cell growth recovery, highlighting a mechanism that maintains granule integrity and enhances survival during chronic stress.