Life beyond 6,000 genes: From sequence to synthesis in a post-genomics era.
- Open access
Complete yeast genome sequencing has transformed biology, enabling genome-scale design and synthetic genomics in Saccharomyces cerevisiae with over 6,000 genes.
- Why it matters: Understanding the yeast genome addresses fundamental questions in eukaryotic biology and supports biotechnological innovations, yet many aspects of its 'dark matter' remain unresolved.
- What they did: The authors review three decades of progress from genome decoding to the omics revolution, highlighting the development of synthetic genomics projects like Sc2.0 and emerging AI and bioelectronics trends.
- The result: This work underscores how comprehensive genomic knowledge facilitates engineering biology, paving the way for future advances in synthetic biology and biotechnological applications.