Meiotic CENP-C supports centromere assembly and kinetochore recruitment in spermatogenesis.

CENP-C is essential for kinetochore recruitment and CID assembly during Drosophila male meiosis, with distinct pools supporting centromere function at different stages.

• Why it matters: Understanding centromere and kinetochore assembly during meiosis is crucial for insights into chromosome segregation errors that can cause infertility or genetic disorders.
• What they did: The study examined the dynamics of CENP-C and CAL1 in prophase I using molecular and cellular approaches, focusing on their roles in centromere maintenance and kinetochore assembly.
• The result: Findings reveal that CENP-C supports centromere stability early in meiosis and kinetochore function later, with separate pools of CID and CENP-C functioning independently, enabling precise chromosome segregation.