Sustainable mevalonate bioproduction: A comprehensive review of microbial biosynthesis and downstream processing technologies.
Microbial biosynthesis can produce over 10 grams per liter of mevalonate, offering a sustainable and cost-effective alternative to chemical synthesis for industrial use.
- Why it matters: Current chemical methods for producing mevalonate face significant limitations, creating a need for greener, more efficient bioproduction strategies to meet industrial demands sustainably.
- What they did: The review analyzes recent advances in microbial MVA biosynthesis, including native and engineered hosts, with approaches like metabolic engineering, mixed cultures, and cell-free systems, along with downstream extraction techniques.
- The result: These innovations enable higher production efficiencies and innovative extraction methods, paving the way for scalable, sustainable mevalonate manufacturing and expanding its industrial applications.