ICAM1high Neutrophils Sculpt Tumor Evolution and Metastasis Through Symbiotic Adhesion and Reverse Migration.
- Open access
ICAM1high neutrophils promote tumor evolution and metastasis by enhancing adhesion and reverse migration in triple negative breast cancer.
- Why it matters: Understanding how immune cells influence tumor progression is crucial for developing targeted therapies, especially given the diverse roles of neutrophils in cancer.
- What they did: The study analyzed neutrophils across human cancers, identifying an ICAM1high subset that interacts with tumor cells, using spatial transcriptomics and tissue microarrays in murine and human TNBC models.
- The result: ICAM1high neutrophils facilitate tumor cell adhesion, promote epithelial-like tumor ecosystems, and enable metastatic intravasation, with implications varying by patient ancestry.