Novel insights into autoimmune gastritis: clinical profile and gastric neoplastic risk from an international multicentre study.

Autoimmune gastritis is associated with a 2.9% incidence of gastric adenocarcinoma and a 10.6% incidence of neuroendocrine tumors across international cohorts.

• Why it matters: Limited comparative data on autoimmune gastritis hinder understanding of regional differences in presentation and neoplastic risk, impacting tailored patient management.
• What they did: A retrospective multicentre study analyzed 1240 adults with histologically confirmed AIG from eight centers in Europe, Türkiye, Latin America, the USA, and Japan, collecting clinical and follow-up data to estimate cancer incidence and associated factors.
• The result: The study found regional variations in presentation and neoplastic risk, with factors such as age over 65, intestinal metaplasia, elevated gastrin-17, and prior PPI use linked to higher odds of adenocarcinoma and NETs, suggesting the need for region-specific follow-up strategies.