An aged human bone marrow mesenchymal niche causes impaired function of human hematopoietic stem cells under regeneration-induced stress

Aged human bone marrow mesenchymal stromal cells impair human hematopoietic stem cell function by promoting myeloid-biased differentiation and weakening protection during regeneration-induced stress.

• Why it matters: Aging reduces hematopoietic stem cell function, but the contribution of the human bone marrow niche has been unclear due to limited experimental models.
• What they did: The study used an experimental model of the aged human bone marrow mesenchymal niche to test how aged versus young hBMSCs regulate young hHSC differentiation and stress protection.
• The result: Aged hBMSCs drive myeloid-biased differentiation of young hHSCs and impair the hBMSC-mediated protective function during regeneration-induced stress.