An Interactive Bidirectional De Novo Protein Design System

An interactive web server combines a structure-aware GNN for de novo sequence design with an ESMFold-based structure predictor in a single bidirectional loop, visualizing sequence–structure mapping.

• Why it matters: Using de novo protein design models is often hard to access and analyze; this tool lowers barriers by enabling interactive validation of design hypotheses and reuse.
• What they did: The server runs in a browser only, visualizes and quantifies both directions of sequence–structure mapping, and includes a Kabsch alignment tool that reports RMSD in the interface.
• The result: The openly sourced, flexible codebase supports interactive analysis, reuse with other researchers’ checkpoints, and optional user-added model structures while keeping the same server workflow.