Gastric resection and restriction yield distinct neuroendocrine and metabolic outcomes in obese mice

In diet-induced obese male C57BL mice, sleeve gastrectomy (SG) and restriction-only gastroplasty (GP) both reduce weight (12% vs 11%) but SG uniquely improves glucose handling and neuroendocrine signaling.

• Why it matters: It remains unclear whether sleeve gastrectomy’s metabolic benefits come from gastric restriction alone or also require tissue resection, limiting rational design of less invasive therapies.
• What they did: Male diet-induced obese C57BL mice were randomized to SG, GP, or sham surgery and assessed over six weeks for energy balance, glucose regulation, hepatic lipid accumulation, circulating hormones/BCAAs, and hypothalamic neuropeptide expression.
• The result: Both procedures improved glucose handling (greater after SG), but only SG reduced hepatic triglycerides and circulating BCAAs and decreased NPY and AgRP, alongside a distinct hormonal profile (higher fasting GLP1 and PYY, lower ghrelin, and larger glucose-stimulated hormone increases).