Contraceptive efficacy of 50 mg Mifepristone once-a-week: an open label, single-arm, multicenter clinical trial in Moldova

Once-weekly 50 mg mifepristone in women aged 18–35 in Moldova produced a perfect-use at-risk Pearl Index of 1.55 (95% CI 0.04–8.64) with 2 pregnancies.

• Why it matters: Unmet contraceptive needs persist due to side effects, dissatisfaction, and contraindications, and evidence for a non-estrogen option using mifepristone remains limited.
• What they did: In an open-label, single-arm, multicenter trial, 146 women used 50 mg mifepristone as their sole method for 13 cycles, and pregnancy due to method failure was assessed as Pearl Index.
• The result: Endometrial thickness increased in 8.9% (11/123) and progesterone receptor modulator-associated changes occurred in 10.6% (13/123) but normalized at follow up, with no hyperplasia or cellular atypia; acceptability was high (95.6%).