Study protocol for a prospective multicenter longitudinal cohort study on progression of moderate aortic valve stenosis, the MODAS Study

The MODAS prospective multicenter cohort will enroll adults with moderate calcific tricuspid aortic stenosis in Germany and follow them up to 5 years to predict progression to severe disease.

• Why it matters: Progression from moderate to severe aortic stenosis is heterogeneous and hard to forecast with conventional echocardiography, limiting earlier diagnosis and treatment.
• What they did: Participants undergo standardized baseline multimodal phenotyping (clinical, labs, ECG, echocardiography, cardiac CT, cardiac MRI) with biomarker, immunologic, proteomic, genetic analyses, and annual follow-up.
• The result: Time to progression to severe aortic stenosis (per 2025 ESC/EACTS criteria) or aortic valve replacement, plus mortality and other trajectories, will support development and validation of prediction models and risk stratification.