CellMethMarker provides an integrated database of human cell- and tissue-type-specific DNA methylation markers

CellMethMarker integrates 347,514 de novo and 2,203,507 literature-derived human cell- and tissue-type DNA methylation markers, enabling region-level retrieval and analysis.

• Why it matters: Existing marker resources focus on disease biomarkers, atlases, genomic annotations, or RNA markers, leaving a need for an integrated, region-level database dedicated to cell- and tissue-specific methylation markers.
• What they did: The team curated CellMethMarker from uniformly processed whole-genome and reduced-representation bisulfite sequencing datasets, plus literature-derived records, totaling 2,810 samples with harmonized metadata.
• The result: In an independent single-cell methylome atlas, the markers recover expected cell-type methylation patterns, and a platform-matched reference reduces mean deconvolution error from 0.365 to 0.144.