High-resolution HLA and MICA/MICB typing of the 1000 Genomes panel: a resource for precision medicine

High-resolution typing of 2,486 1000 Genomes Phase 3 individuals across 13 HLA and MIC loci produced HLA genotypes with 96.2–97.4% two-field concordance and enabled MIC prediction.

• Why it matters: Existing public MHC reference datasets lack resolution and coverage, limiting transplantation matching, immunogenetic interpretation, and disease-association analyses.
• What they did: The study generated HLA genotypes for 2,486 individuals and MICA/MICB genotypes for 2,393 individuals across 25 populations, then assessed concordance and performed cross-validation MIC genotype prediction from HLA.
• The result: Five-fold cross-validation using two-field HLA-B and HLA-C achieved exact genotype prediction accuracies of 77.3% for MICA and 53.6% for MICB, versus 4.6% and 21.6% without HLA information.