bioRxiv · 25 Sept 2026 · Preprint

β3-Integrin controls pericyte metabolic states and shapes tumour-stromal metabolic crosstalk in breast cancer

Heylen, Jordan + 10 more

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PDE5A Inhibition Restricts Cancer Metastasis by Disrupting NPC1-Mediated Cholesterol Trafficking through a Noncanonical cGMP-Dependent Pathway.
Cancer Research · 2 Oct 2026 · Journal Article
PDE5a inhibitors like sildenafil reduce cancer metastasis by disrupting NPC1-mediated cholesterol trafficking, causing lysosomal cholesterol accumulation and impairing cell migration.
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Targeting p300 Reverses Acidic Microenvironment-Induced PARP Inhibitor Resistance.
Cancer Research · 2 Oct 2026 · Journal Article
Acidic tumor microenvironment activates p300, causing a 50% reduction in PARPi effectiveness in epithelial ovarian cancer.
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Diet-Induced Phospholipid Remodeling Dictates Ferroptosis Sensitivity and Tumorigenesis in the Pancreas.
Cancer Discovery · 1 Oct 2026 · Journal Article
Dietary unsaturated fatty acids differentially influence pancreatic cancer progression by modulating ferroptosis sensitivity, with MUFAs promoting and PUFAs inhibiting tumor development.
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- 1 cites
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https://jclub.com.au/a/42053430
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