bioRxiv · 3 Sept 2026 · Preprint · Open access

Extravascular coagulation stabilizes pro-fibrotic stromal states via tumor-intrinsic PAR1 signaling in pancreatic ductal adenocarcinoma

Choi, Munoz + 13 more

Open access

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Acquired resistance to the RAS(ON) multi-selective inhibitor daraxonrasib guides rational combination therapy strategies in pancreatic cancer.
Nature Medicine · 1 Aug 2026 · Clinical Trial, Phase II
Over 59% of pancreatic cancer patients treated with daraxonrasib develop resistance through RAS pathway alterations, including KRAS amplification and RTK upregulation.
- Open access
- 5 cites
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CDK8 remodels the tumor microenvironment and promotes resistance to KRAS(G12D) inhibitors and daraxonrasib in PDAC.
EMBO Journal · 1 Aug 2026 · Journal Article
CDK8 drives immune evasion and resistance in PDAC by remodeling the tumor microenvironment during KRAS G12D inhibition, with 50% of cases showing resistance.
- Open access
- 3 cites
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Daraxonrasib or Chemotherapy in Previously Treated Metastatic Pancreatic Cancer.
New England Journal of Medicine · 23 July 2026 · Randomized Controlled Trial
Daraxonrasib significantly improves overall survival and progression-free survival in previously treated metastatic pancreatic ductal adenocarcinoma, with median overall survival of 13.2 months versus 6.6 months for chemotherapy.
- 97 cites
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