bioRxiv · 1 Oct 2026 · Preprint · Open access

A Spin-Glass Metabolic Hamiltonian optimized by Quantum Annealing Reveals Configurational Regimes of Cancer Metabolism

Sung, Baek + 3 more

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Targeting p300 Reverses Acidic Microenvironment-Induced PARP Inhibitor Resistance.
Cancer Research · 2 Oct 2026 · Journal Article
Acidic tumor microenvironment activates p300, causing a 50% reduction in PARPi effectiveness in epithelial ovarian cancer.
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From Tissue Specificity to Systemic Cues: Shaping MYC-Driven Tumor Metabolism.
Cancer Research · 2 Oct 2026 · Review
MYC drives tissue-specific and systemic metabolic reprogramming in tumors, creating context-dependent vulnerabilities that can be targeted for therapy.
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https://jclub.com.au/a/42446901
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KDM6A loss enhances oxidative phosphorylation uncovering tissue-level convergent evolution.
EMBO Journal · 1 Oct 2026 · Journal Article
Loss of KDM6A enhances oxidative phosphorylation across multiple tissues, revealing a conserved mechanism of tissue-level convergent evolution in cancer and development.
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