Coiled-coil homo-oligomerization and disaggregase Hsp104 act in parallel to stabilize orphan septins

Coiled-coil homo-oligomerization and Hsp104 disaggregase work together to stabilize orphan septins in yeast cells.

• Why it matters: Maintaining proper septin assembly is crucial for cell function, yet orphan septins tend to aggregate and are linked to neurodegenerative diseases, highlighting a gap in understanding how cells prevent this.
• What they did: The study examined yeast septins, showing that orphan septins form transient coiled-coil homodimers and trimers, and that Hsp104 assists in preventing their aggregation, especially when CTD-mediated oligomerization is impaired, across 100-150 words.
• The result: Findings demonstrate that coiled-coil interactions and Hsp104 collaboratively protect orphan septins from degradation, ensuring proper assembly and stability, which advances understanding of cellular proteostasis and septin regulation.