bioRxiv · 25 Sept 2026 · Preprint

SWI/SNF-Dependent Chromatin Remodelling Establishes Gene Regulatory Programs in Early Human Embryos and Blastoids

van Knippenberg, Tryfonos + 17 more

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ALKBH5 in Cancer-Associated Fibroblasts Governs an Epitranscriptomic Axis That Drives Pancreatic Cancer Metastasis.
Cancer Research · 2 Oct 2026 · Journal Article
ALKBH5-driven epitranscriptomic changes in cancer-associated fibroblasts promote pancreatic cancer metastasis independently of primary tumor growth.
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High-Risk Rhabdomyosarcomas Feature a Convergent Cell State.
Cancer Research · 2 Oct 2026 · Journal Article
High-risk rhabdomyosarcomas share a common neural-like cell state, regardless of FOXO1 fusion status, revealing a convergent transcriptional phenotype in lethal cases.
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Dual E3 ligase recruitment by monovalent degraders for tunable SMARCA 2/4 degradation.
Nature Chemical Biology · 1 Oct 2026 · Journal Article
Monovalent degraders can recruit two E3 ligases simultaneously to degrade SMARCA2/4, with tunable dependency on DCAF16 or FBXO22.
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