bioRxiv · 29 Sept 2026 · Preprint · Open access

Functional dissection of SPOP on the amino acid level reveals a comprehensive functional landscape of variants during tumorigenesis

Park, Lee + 8 more

Open access
1 cites

Abstract ↗AI briefThe abstract is read at the publisher; the brief is JClub's.

The AI brief for this paper is being written. Open it in JClub to read the paper with the brief as soon as it lands.

Read the brief in JClub →

Targeting p300 Reverses Acidic Microenvironment-Induced PARP Inhibitor Resistance.
Cancer Research · 2 Oct 2026 · Journal Article
Acidic tumor microenvironment activates p300, causing a 50% reduction in PARPi effectiveness in epithelial ovarian cancer.
Open
Share
Post on X Post on Bluesky Share on LinkedIn
https://jclub.com.au/a/42467549
Open in JClub
From Tissue Specificity to Systemic Cues: Shaping MYC-Driven Tumor Metabolism.
Cancer Research · 2 Oct 2026 · Review
MYC drives tissue-specific and systemic metabolic reprogramming in tumors, creating context-dependent vulnerabilities that can be targeted for therapy.
Open
Share
Post on X Post on Bluesky Share on LinkedIn
https://jclub.com.au/a/42446901
Open in JClub
KDM6A loss enhances oxidative phosphorylation uncovering tissue-level convergent evolution.
EMBO Journal · 1 Oct 2026 · Journal Article
Loss of KDM6A enhances oxidative phosphorylation across multiple tissues, revealing a conserved mechanism of tissue-level convergent evolution in cancer and development.
- Open access
Open
Share
Post on X Post on Bluesky Share on LinkedIn
https://jclub.com.au/a/42697963
Open in JClub

Journals this month

All journals →

Moving areas, week to 3 Oct 2026

All research areas →

Read