bioRxiv · 8 Sept 2026 · Preprint · Open access

A state-structured pharmacodynamic framework separating resistance, tolerance and persistence, applied to Mycobacterium tuberculosis and Staphylococcus aureus

Piranfar, V.

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Polyketide synthase 12 is an in vivo essential source of novel mycolyl lipids in Mycobacterium tuberculosis
bioRxiv · 25 Sept 2026 · Preprint
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Identifying a novel mechanism of L-leucine uptake in Mycobacterium tuberculosis using a chemical genomic approach.
eLife · 23 Sept 2026 · Journal Article
Semapimod inhibits L-leucine uptake in Mycobacterium tuberculosis, reducing bacterial load in infected mice despite no in vitro efficacy.
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Tobramycin enhances Mycobacterium abscessus fitness through whiB7 induction.
Proceedings of the National Academy of Sciences · 22 Sept 2026 · Journal Article
Tobramycin increases Mycobacterium abscessus survival by inducing whiB7, promoting persistent infection in cystic fibrosis airway conditions.
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